Recent Advances
Identifieur interne : 002501 ( Main/Exploration ); précédent : 002500; suivant : 002502Recent Advances
Auteurs : A. Barbato [Italie] ; C. Panizzolo [Italie]Source :
- Paediatric Respiratory Reviews [ 1526-0542 ] ; 2000.
English descriptors
- KwdEn :
- Teeft :
- Adult patients, Aetiological agent, Alveolar macrophages, Alveolar spaces, Alveolar wall, Biopsy, Bronchiolitis obliterans, Bronchoalveolar lavage, Carbon monoxide, Cell surface, Chloroquine, Chloroquine treatment, Clinical history, Corticosteroid, Corticosteroid therapy, Crit, Desquamative, Diagnostic approach, Diagnostic value, Early stages, Fibrosing alveolitis, Growth factors, Harcourt publishers, High morbidity, High resolution, Histological, Histological features, Histological picture, Hrct, Hypersensitivity pneumonitis, Idiopathic, Immune complexes, Immune response, Immunocompetent children, Interstitial, Interstitial fibrosis, Interstitial lung disease, Interstitial pneumonia, Invasive tests, Lung, Lung bases, Lung biopsy, Lung disease, Macrophage, Mesenchymal cells, Neutrophil, Normal lung, Normal ratio, Open lung biopsy, Oral steroids, Pediatr, Pediatr pulmonol, Pneumonia, Pneumonitis, Potential cause, Pulmonary function tests, Pulmonary hypertension, Pulmonol, Recurrent aspiration, Respir, Respir crit care, Respiratory function tests, Thoracoscopic biopsy, Total lung capacity, Transbronchial biopsy, Various forms, Vital capacity, Weight loss.
Abstract
Abstract: Chronic interstitial lung disease (ILD) is rare in children, but is clinically relevant because of its high morbidity and mortality rates. Several aetiological agents may have a role in this disease and various aetiopathogenic forms have been described, although they share a characteristic evolution towards pulmonary fibrosis. The aetiology sometimes remains unknown, in which case we speak of idiopathic interstitial pneumonia (IIP). Diagnosis relies on non-invasive methods (clinical history, respiratory function tests, chest X-ray and high-resolution CT scan) and invasive techniques (bronchoalveolar lavage, transbronchial biopsy, video-assisted thoracoscopic biopsy and open lung biopsy); the latter are used when the former fail to identify an aetiological agent. The gold standard for the diagnosis is lung biopsy, however, which also enables the classification of the idiopathic forms, in particular (usual interstitial pneumonia, desquamative interstitial pneumonia, non-specific interstitial pneumonia, and so on). In ILD, the most common therapeutic approaches involve the use of oral steroids and hydroxychloroquine sulphate for its anti-inflammatory and antifibrotic effect. The prognosis is often poor.
Url:
DOI: 10.1053/prrv.2000.0034
Affiliations:
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<term>Aetiological agent</term>
<term>Alveolar macrophages</term>
<term>Alveolar spaces</term>
<term>Alveolar wall</term>
<term>Biopsy</term>
<term>Bronchiolitis obliterans</term>
<term>Bronchoalveolar lavage</term>
<term>Carbon monoxide</term>
<term>Cell surface</term>
<term>Chloroquine</term>
<term>Chloroquine treatment</term>
<term>Clinical history</term>
<term>Corticosteroid</term>
<term>Corticosteroid therapy</term>
<term>Crit</term>
<term>Desquamative</term>
<term>Diagnostic approach</term>
<term>Diagnostic value</term>
<term>Early stages</term>
<term>Fibrosing alveolitis</term>
<term>Growth factors</term>
<term>Harcourt publishers</term>
<term>High morbidity</term>
<term>High resolution</term>
<term>Histological</term>
<term>Histological features</term>
<term>Histological picture</term>
<term>Hrct</term>
<term>Hypersensitivity pneumonitis</term>
<term>Idiopathic</term>
<term>Immune complexes</term>
<term>Immune response</term>
<term>Immunocompetent children</term>
<term>Interstitial</term>
<term>Interstitial fibrosis</term>
<term>Interstitial lung disease</term>
<term>Interstitial pneumonia</term>
<term>Invasive tests</term>
<term>Lung</term>
<term>Lung bases</term>
<term>Lung biopsy</term>
<term>Lung disease</term>
<term>Macrophage</term>
<term>Mesenchymal cells</term>
<term>Neutrophil</term>
<term>Normal lung</term>
<term>Normal ratio</term>
<term>Open lung biopsy</term>
<term>Oral steroids</term>
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<term>Pediatr pulmonol</term>
<term>Pneumonia</term>
<term>Pneumonitis</term>
<term>Potential cause</term>
<term>Pulmonary function tests</term>
<term>Pulmonary hypertension</term>
<term>Pulmonol</term>
<term>Recurrent aspiration</term>
<term>Respir</term>
<term>Respir crit care</term>
<term>Respiratory function tests</term>
<term>Thoracoscopic biopsy</term>
<term>Total lung capacity</term>
<term>Transbronchial biopsy</term>
<term>Various forms</term>
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<term>Weight loss</term>
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<front><div type="abstract" xml:lang="en">Abstract: Chronic interstitial lung disease (ILD) is rare in children, but is clinically relevant because of its high morbidity and mortality rates. Several aetiological agents may have a role in this disease and various aetiopathogenic forms have been described, although they share a characteristic evolution towards pulmonary fibrosis. The aetiology sometimes remains unknown, in which case we speak of idiopathic interstitial pneumonia (IIP). Diagnosis relies on non-invasive methods (clinical history, respiratory function tests, chest X-ray and high-resolution CT scan) and invasive techniques (bronchoalveolar lavage, transbronchial biopsy, video-assisted thoracoscopic biopsy and open lung biopsy); the latter are used when the former fail to identify an aetiological agent. The gold standard for the diagnosis is lung biopsy, however, which also enables the classification of the idiopathic forms, in particular (usual interstitial pneumonia, desquamative interstitial pneumonia, non-specific interstitial pneumonia, and so on). In ILD, the most common therapeutic approaches involve the use of oral steroids and hydroxychloroquine sulphate for its anti-inflammatory and antifibrotic effect. The prognosis is often poor.</div>
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